Endocrine Abstracts

Background and aims: The prevalence of gestational diabetes (GDM) increases worldwide with rates between 9 and 35%. The management of GDM is a labor-intensive discipline, in which the global increase in GDM prevalence poses challenges to maintain high-quality care. A valuable solution could be the organization of group education. The ELENA study therefore aimed to evaluate women’s satisfaction about (group) education and treatment, their knowledge about GDM and whether th...

Background: Little is known about the influence of the Predictive Low Glucose suspend (PLGS) function of Sensor Augmented Pump therapy on ketone production in patients with type 1 diabetes mellitus (T1DM), compared to the Low Glucose Suspend function. To evaluate the effect, we compared the frequency of elevated ketone levels, the duration of insulin infusion suspension, the glycaemic control and patient satisfaction between the two settings.Methodology:...

Aims: To identify factors associated with early postpartum weight retention (PPWR) in women with recent gestational diabetes mellitus (GDM).Methods: Multicentric prospective study in women with a recent history of GDM based on the IADPSG criteria at the oral glucose tolerance test (OGTT) 6-16 weeks postpartum. Data obtained from electronic medical records, self-administered questionnaires, clinical examination and blood sample collection were used for th...

Aims: To determine predictors of neonatal adiposity and differences in associations by fetal sex in women with gestational diabetes mellitus (GDM), normal-weight and overweight (BMI ≥ 25 kg/m²) normal glucose tolerant women (NGT).Methods: Skinfold thickness was measured in 576 newborns, and cord blood leptin, c-peptide and lipids in 327 newborns in a multi-centric prospective cohort study.Results: Compared to ...

Aims: To determine the fasting plasma glucose (FPG) level at which an oral glucose tolerance test (OGTT) could be avoided to screen for gestational diabetes (GDM) and to evaluate the characteristics of women across this FPG threshold.Methods: A multi-centric prospective cohort study (BEDIP-N) with 1843 women receiving screening for GDM with a 75g OGTT.Results: A FPG < 78 mg/dl was the FPG cut-off with the best trade-off to limi...

Aims: To compare the characteristics, pregnancy outcomes and tolerance of screening tests between women who prefer a two-step screening strategy with a glucose challenge test (GCT), women who prefer an one-step screening strategy with an oral glucose tolerance test (OGTT) and women without clear preference for screening method for gestational diabetes mellitus (GDM). Methods: 1803 women from a Belgian multi-centric prospective cohort study (BEDIP-N study...

Aim: To determine the association between thyroid function and the risk for gestational diabetes mellitus (GDM) and adverse pregnancy outcomes.Methods: This case-control study was a sub-analysis of the BEDIP-N study, in which 199 GDM women were matched for age and body mass index with 398 controls. Thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3), and thyroid peroxidase (TPO) antibodies were measured at 6-14 weeks and ...

Aims: To determine the impact of antenatal depression on pregnancy outcomes in women with gestational diabetes mellitus (GDM) and women with normal glucose tolerance (NGT).Methods: 1843 women from a Belgian multi-centric prospective cohort study (BEDIP-N Study) received universal screening for GDM with a 75 g OGTT and the IADPSG criteria. The Center for Epidemiologic Studies – Depression (CES-D) questionnaire was completed at the time of the OGTT (b...